The Buffalo Bills and San Francisco 49ers will meet at Highmark Stadium in Week 13 of the 2024 NFL season.
The Bills are coming off a bye week and are 9-2 on the season. The 49ers are 5-6 and lost to the Green Bay Packers last week, 38-10.
This is the fifth time the Bills are playing in prime-time this year and they are 3-1, though the loss did come in their only other Sunday Night Football appearance.
Here’s how to watch the Bills game, including time, TV schedule and streaming information:
Cable/Network TV:  NBC. The game will be available locally via the following stations: WHEC channel 10 (Rochester area), WGRZ channel 2 (Buffalo area), WSTM channel 3 (Syracuse area), WKTV channel 2 (Utica area), WETM channel 18 (Elmira area), WNYT channel 13 (Albany area), and WBGH channel 20 (Binghamton area).
Start time: 8:20 p.m.
Bills vs 49ers will broadcast nationally on NBC in Week 13 of the 2024 NFL season. Mike Tirico and Cris Collinsworth will call the game from the booth at Highmark Stadium, with Melissa Stark reporting from the sidelines.
You can watch games on NFL.com and the NFL mobile app, and you can subscribe to NFL+, the league’s own streaming service, though you can’t cast the games to your TV – you must watch on your phone or tablet.
TV streaming:  You can also stream if you have subscriptions to Spectrum, DirecTV, fuboTVSling, Vidgo, Hulu + Live TV, YouTube TV, and Peacock.
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If Miami loses Thursday, the Bills will take the field with a chance to wrap up their fifth consecutive AFC East title. If Miami wins, that’s all the more reason for the Bills – who have to go on the road to the Rams and Lions after this – to want to take care of business and keep the Dolphins on the brink of extinction in the division race.
San Francisco’s health will be a major factor. It’s too early in the week to guess at whether Purdy, Williams, Ward and Bosa can return, but there are indications that all four of them will do so, making Buffalo’s task much more difficult than Green Bay’s was. Still, the Bills are at home where they’re 5-0 this season and 32-6 since the start of 2020, and that could prove to be the eventual difference.
Sal Maiorana’s prediction: Bills 27, 49ers 20
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Sal Maiorana has covered the Buffalo Bills for four decades including 35 years as the full-time beat writer for the D&C, and he has written numerous books about the history of the team. He can be reached at maiorana@gannett.com, and you can follow him on Twitter @salmaiorana.https://profile.democratandchronicle.com/newsletters/bills-blast
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