It’s Week 6, folks! Time to set those fantasy lineups! Start ‘Em, Sit 'Em is the ultimate look at the best and worst matchups in a given week for fantasy football leagues. Each week, I'll examine the wide receivers who could exceed or fail to meet expectations based on their weekly opponent … like Brian Thomas Jr. and Dionte Johnson in Week 5!
For your final lineup decisions, check out my fantasy player rankings. I update them daily! Also, make sure you subscribe to the Fantasy Dirt Podcast with Lindsay Rhodes and I, as we break down all things fantasy football five days a week!
1. CeeDee Lamb vs. Lions
2. Malik Nabers vs. Bengals
3. Amon-Ra St. Brown at Cowboys
4. Ja'Marr Chase at Giants
5. A.J. Brown vs. Browns
6. Drake London at Panthers
7. Jayden Reed vs. Cardinals
8. DK Metcalf vs. 49ers (Thurs.)
9. DJ Moore vs. Jaguars
10. Chris Godwin at Saints
Complete Week 6 wide receiver rankings
Byes: Chiefs, Dolphins, Rams, Vikings
DJ Moore vs. Jaguars (London, 9:30 a.m. ET, NFL Network): Moore is coming off his best stat line of the season, scoring 27.5 fantasy points after averaging 11.9 points in his prior four games. He should remain hot this weekend across the pond against a Jags defense that’s allowed 147.4 receiving yards and the most fantasy points to opposing perimeter receivers. They’ve allowed the most PPR points to wideouts overall, too.
Marvin Harrison Jr. at Packers (1 p.m. ET, Fox): Harrison Jr. posted a stinker last week, scoring just 5.6 fantasy points in a win over the 49ers. He had scored 15-plus points in his previous three games, however, and a matchup in Green Bay is favorable. Their defense has allowed the fourth-most points to perimeter receivers, including six touchdowns. This could change if CB Jaire Alexander returns, but for now, Harrison Jr. is a start ‘em.
Terry McLaurin at Ravens (1 p.m. ET, CBS): McLaurin has been on fire in recent weeks, scoring 18-plus points in two of his last three games. He should remain in starting lineups this week too, as the veteran faces a Ravens defense that’s given up the third-most points to perimeter receivers. Last week, this unit allowed more than 70 combined points to the duo of Ja’Marr Chase and Tee Higgins. Consider McLaurin a solid No. 2 wideout.
Zay Flowers vs. Commanders (1 p.m. ET, CBS): Flowers has been inconsistent this year, but he has scored 19 or more points in two of his last four games. He also has a favorable matchup against the Commanders this week, as their defense has surrendered a league-high 10 touchdown catches and the seventh-most fantasy points to wide receivers. This could end up being a high-scoring affair, so Flowers is a nice WR2 option this week.
Diontae Johnson vs. Falcons (4:25 p.m. ET, Fox): Johnson, listed as a sit 'em last week, had his worst stat line since Andy Dalton took over as Carolina's quarterback. I think he'll rebound this week though, as he'll face an Atlanta defense that allowed Mike Evans to beat them for two touchdowns last week. In all, the Falcons have allowed six different wideouts to beat them for 13-plus points including three how have scored over 20 fantasy points.
George Pickens at Raiders (4:05 p.m. ET, CBS): Pickens has been tough to trust so far this season, scoring fewer than 11 points in three of his last four games including just 5.6 points against Dallas last week. I’d keep that in mind against the Raiders, who have given up an average of 77.6 receiving yards and just one touchdown to perimeter receivers. At best, Pickens will be a risk-reward flex starter in a game with a low 36.5-point total at FanDuel Sportsbook.
Amari Cooper at Eagles (1 p.m. ET, Fox): Cooper actually has a great matchup on paper against the Eagles, but I'm not sure how you can start any Browns right now. Their offense is a disaster, Deshaun Watson looks like a shell of his former self, and his offensive line is terrible. As for Cooper, he has scored more than 10 points just once this season, and he's been held to single digits three times. He's just impossible to trust right now.
Christian Kirk vs. Bears (London, 9:30 a.m. ET, NFL Network): Kirk has recorded some nice totals in recent weeks, scoring at least 12.8 points in three straight games. I do worry about his snaps, however, as he saw a season-low 31 last week in a win over the Colts. He also had a bad matchup against the Bears, who have allowed the ninth-fewest points per game to receivers and no touchdowns to slot receivers this season.
Courtland Sutton vs. Chargers (4:05 p.m. ET, Fox): Sutton has been tough to trust, as he’s scored in single digits in three of his first five games of the season. That includes a 5.2-point stinker against the Raiders last week. He’s a gamble this week too, as Sutton faces a Chargers defense that’s allowed 75.3 receiving yards and just 14.6 fantasy points per game to opposing perimeter receivers. I’d keep Sutton on the sidelines.
Jakobi Meyers vs. Steelers (4:05 p.m. ET, CBS): Meyers has seen his value rise in the last few weeks, as he’s scored a combined 44.3 fantasy points in the last three games. He’s also seen at least nine targets in all of those games, which has much to do with the whole Davante Adams situation. Regardless, he’ll be no more than a risky flex option against the Steelers. Their defense has allowed just 88.3 receiving yards per game to the perimeter.
Michael Fabiano is a fantasy football analyst for Sports Illustrated. Before joining SI in August 2020, he worked for CBS Sports, NFL Network and SiriusXM. He also contributes to Westwood One Radio and the Bleav Podcast Network. Fabiano was the first fantasy analyst to appear on one of the four major TV networks and is a member of the Fantasy Sports Writers Association Hall of Fame.
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