Week 13 has delivered multiple memorable moments around the league, and the Buffalo Bills and San Francisco 49ers are looking to put their stamp on one in the final game of Sunday’s action. Highmark Stadium in Orchard Park, New York, was blanketed by snow over the weekend, but things should be clear for the game.
The Bills return from their bye and will look to keep pace with the Kansas City Chiefs at the top of the AFC. Josh Allen has Buffalo humming, winning six consecutive games while scoring 30 points or more in five straight. The Bills can secure their fifth consecutive AFC East crown with a win on “Sunday Night Football.”
The visiting 49ers come into this showdown with a 5-6 record. For the first time since 2020, the defending NFC champs have a losing record this late in the season. Running back Christian McCaffrey will play in his fourth game after missing the first two months of the season and will look to make an impact against a Bills defense tied with the fourth-highest yards per carry allowed entering Week 13.
Quarterback Brock Purdy is expected to return under center for the Niners after he missed last week’s game against the Green Bay Packers with a right shoulder injury. The Bills have afforded themselves a cushion in the AFC East, but the 49ers find themselves with their backs against the wall with six games remaining in the regular season.
USA TODAY Sports will provide live updates, highlights and more from the “Sunday Night Football” matchup between the Bills and 49ers below. All times are Eastern.
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49ers star running back Christian McCaffrey headed back to the locker room after his trip to the medical tent. The team announced he has a knee injury and is questionable to return to tonight’s game.
On the first play of the Bills’ second drive of the game, James Cook took off down the right sideline and broke away from every defender for a 65-yard rushing touchdown.
Tyler Bass knocked through the ensuing PAT, and it’s 14-3 Bills with 8:38 remaining in the first half.
The 49ers’ drive ended after nine plays and 48 yards at the Buffalo 27. Jake Moody’s second field goal attempt of the night had the range but ended up wide left.
It’s still 7-3 Bills with 8:48 left in the second quarter.
On a first down play in the second quarter, 49ers running back Christian McCaffrey took a handoff but slid behind the line of scrimmage for a five-yard loss just a few steps into his run. He immediately jogged off of the field and entered the blue medical tent on the 49ers’ sideline after the play.
According to NBC sideline reporter Melissa Stark, both teams have chicken broth and hot chocolate on their sidelines to battle the cold. It’s 27 degrees and snowing in Orchard Park, New York, but it feels like 17 degrees with the 11 mph winds.
Buffalo took the lead with a 70-yard touchdown drive that included four successful third-down conversions, one of which was a gritty, seven-yard run by quarterback Josh Allen. It was Ray Davis who crossed the goal line in the end. His 5-yard rush followed a 13-yard run up the middle on third-and-1 one play earlier.
It’s 7-3 Bills at the end of the first quarter.
The 49ers forced a three-and-out on the Bills’ opening drive, then put together a nine-play, 48-yard drive that stalled at the Buffalo 15. Jake Moody knocked through his first field goal attempt of the night to get the first points on the board.
San Francisco leads Buffalo, 3-0, with 7:41 left in the first quarter.
The Bills and 49ers game will wrap up Sundays Week 13 of the 2024 NFL season with “Sunday Night Football” at 8:20 p.m. ET. 
Here’s how the USA TODAY Sports staff feels the Week 13 “SNF” matchup between the Bills and 49ers will shape up: 
According to the Weather Channel, it’s going to be a cold night in Orchard Park with a high of 30 degrees at kickoff and a low of 29 degrees at midnight. The good news, the wind will not be much of a factor with gusts topping out at 10 MPH. There is a slight chance of snow showers with little to no accumulation.
For cord cutters looking for a live stream for the matchup, you can turn to Fubo TV. Fubo TV carries NBC, as well as CBS, FOX, NFL Network and the ESPN family of networks, meaning you can catch NFL action through the remainder of the season. 
Peacock, the proprietary streaming service of NBC, will also carry the game. 
The Bills are favorites to defeat the 49ers, according to the BetMGM NFL odds. Not interested in this game? Check out expert picks and best bets for every NFL game this week.   
Mack Hollins is walking in a winter wonderland, barefoot.
The Buffalo Bills receiver seemingly isn’t worried about the cold, especially as over a foot of snow is dumped on the region. Hollins donned some all-white attire ahead of the “Sunday Night Football” game against the 49ers. Without socks or shoes, the receiver walked through the shoveled parking lot, although the pavement was likely freezing. — Nick Brinkerhoff
Mike Tirico will handle play-by-play duties during the game, with Cris Collinsworth providing color commentary and Melissa Stark reporting from the sidelines during 49ers vs. Bills. 
NBC’s weekly “Football Night in America” pregame show begins at 7 p.m. ET and feature insight from a panel of analysts, including Maria Taylor, Jason Garrett, Chris Simms, Mike Florio, Devin McCourty, Tony Dungy, and more. 
These interconference opponents have met 13 times in NFL history. The Bills lead the matchup all-time with a 7-6 record.  
The most recent meeting between these teams was in December 2020 when the Bills won in impressive fashion on the road. Josh Allen threw for 375 yards and tossed four touchdown passes as the Bills stayed in sole possession of first place in the AFC East at the time.
During the 1992 season, the 49ers and Bills had a memorable, high-scoring encounter in which there was more than 1,000 yards of offense and no punts. The Bills won the game, 34-31.
The New England Patriots and Pittsburgh Steelers are tied for the most Super Bowl wins with six. 
Pittsburgh and Dallas have the unique distinction of playing each other more than any other team combination in Super Bowl history with three matchups. 
The 49ers have eight total Super Bowl appearances and five rings to show for it, the most recent coming during the 1994 season in Super Bowl XXIX. The Bills have four Super Bowl appearances, which came in consecutive seasons in 1990-93, but no victories.
NFL franchises with most Super Bowl wins:
➤ Super Bowl winners: All-time scores, results for NFL title game
The NFL’s top 18 players in average annual salary are all quarterbacks, according to OverTheCap.comDallas Cowboys quarterback Dak Prescott became the league’s highest-paid player before the 2024 season, agreeing to a four-year, $240 million dealMinnesota Vikings wide receiver Justin Jefferson is the first non-quarterback on the highest-paid list after striking a four-year, $140 million contract extension this offseason.  
➤  Complete list of the league’s highest-paid players 
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